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TB-500 (Thymosin Beta-4)



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Buy TB-500 for Sale

TB-500 is a synthetic replica of Thymosin Beta 4, a natural peptide that occurs in virtually all human and animal cells. TB-4 plays an important role in blood vessel formation, reducing inflammation, and regulating wound healing in the body.

TB-4 has been shown to regenerate injured or damaged tissues and reduce oxidative damage in the heart and central nervous system. Additionally, it was found to alleviate high blood sugar levels and improve insulin in a mouse model of type-2 diabetes.


What is TB 500?

TB-500 is a man-made version of Thymosin Beta 4, a naturally occurring peptide. This natural peptide plays a vital role in angiogenesis or the formation of new blood vessels in the body. TB4 also inhibits the polymerization of actin into actin filaments.

TB 500 possesses the potential ability to repair the heart following a heart attack. This was shown in a phase 2 clinical trial involving acute myocardial infarction (MI) patients. In the trial, TB-4 treatment decreased scar formation and regenerated heart tissues.

Recent studies have shown that TB 500 may reduce inflammation of tissues in joints, encourage tissue repair following injury, and prevent the formation of muscle adhesions. This peptide has also demonstrated the ability to improve glucose tolerance.

In preclinical studies, TB-4 encouraged the proliferation of osteoblasts, cells that are responsible for bone formation. It is vital to note that TB-500 isn’t approved for human consumption by the FDA. sells it for laboratory research use only.


How Does TB 500 Work?

Research has shown that TB 500 (TB-4) works by:


Up-regulating the Action of Actin

TB 500 works by up-regulating the action of actin in eukaryotic cells. It also blocks actin polymerization to increase the levels of this cell-building protein in the body. [R]

Actin is a protein that is normally found in all eukaryotic cells. It plays an important role in muscle contraction, the function of smooth muscle, and the formation of cells that help maintain bone density. Actin is also involved in cell migration, cell differentiation, and tissue repair.


Encouraging Angiogenesis

TB 4 has also been shown to encourage blood vessel formation. [R]

This was demonstrated in a rat study in which one group was given TB4 and the other a placebo. Final results showed an increased expression of genes associated with angiogenesis among the TB-4 group. Increased angiogenesis is crucial to wound healing and tissue repair. [R]


TB 500 Research

Multiple clinical and preclinical studies have examined the potential effects of TB 500 (TB-4). These studies have examined the impact of this peptide on heart health, muscle growth, wound healing, diabetes, and other conditions. Here are the key findings:


1. TB 500 and Heart Health

Research shows that TB-4 could protect, repair, and regenerate the heart.

According to a phase 2 clinical trial, TB-4 reduced the volume of scars in the hearts of patients who had recently suffered a heart attack. The volume of scars in the heart following a heart attack is an indicator of the amount of damage that has been done to the heart muscle. [R]

In a preclinical myocardial infarction (MI) model, TB-4 treatment was linked with reduced cardiac remodeling and improved left ventricular function. While some degree of cardiac modeling is needed to repair the heart after MI, excessive remodeling can damage the heart. [R]

Finally, TB-4 has been shown to assist with three main aspects of cardiac regeneration. It has been found to support resident cardiomyocyte survival and repair, modulate the inflammatory environment within the damaged heart, and promote new blood vessel formation in the heart. [R]


2. TB 500 and Wound Healing

Multiple studies have shown that TB-4 accelerates wound healing by promoting cell migration and stem cell mobilization. Other mechanisms with which it expedites wound healing include the inhibition of inflammation, apoptosis, and infection. [R]

In a rat model of the full-thickness wound, adding TB-4 topically or through a body cavity increased reepithelialization (skin cell regrowth after injury) and wound contraction vis-à-vis saline controls. Both are vital components of the healing process. [R]

In an in-vivo study of corneal alkali injury, TB-4 treatment promoted wound healing and reduced inflammation. This is significant as alkali causes the most severe type of injury. [R]


3. TB 500 and Dry Eye

In a phase-2 clinical trial, TB-4 eye drops significantly improved signs and symptoms of dry eye, a condition that affects over 16 million Americans.

This 28-day placebo-controlled trial was conducted on nine patients with severe dry eye. After a 28-day TB-4 treatment, visible reductions in ocular discomfort were observed. Other improvements seen in treated patients included increased tear volume production. [R]

Significantly, the improvements in the signs and symptoms of the disease lasted beyond the treatment period.


4. TB 500 and Diabetes

TB4 may be an effective treatment for diabetes and associated complications.

In a mouse model of type-2 diabetes mellitus (T2DM), TB-4 treatment was linked with a significant reduction in glucose profiles in the treated group. Additionally, this synthetic peptide ameliorated the mice’s insulin resistance. [R]

Another preclinical study reported that TB-4 promoted the recovery of peripheral neuropathy. PN is one of the most common complications of T2DM. Data from the study shows that TB4 improved various functions typically impaired by this condition. [R]


5. TB 500 and Inflammation

Multiple studies have reported that TB4 possesses anti-inflammatory properties.

This peptide modulates inflammation by inhibiting the production of pro-inflammatory cytokines and encouraging the production of anti-inflammatory cytokines. Another way it plays an anti-inflammatory role is by regulating the polymerized G-actin sequence. [R]

Its anti-inflammatory properties are partially responsible for this peptide’s ability to boost heart health, expedite wound healing, and accelerate tissue regeneration.


6. TB 500 and Neuroprotection

Research has shown that TB4 could induce neuroprotection.

In a mouse model of traumatic brain injury (TBI), TB4 treatment initiated 6 hours post-injury provided both neuroprotection. Additionally, this research chemical induced neurorestoration by improving spatial learning and neurogenesis in animal cells. [R]

Similar results were reported in an animal model of spinal cord injury. Additionally, in a mice model of multiple sclerosis, TB4 treatment delayed the onset of the disease. It also evoked a significantly improved recovery in neurological function. [R]


Frequently Asked Questions

What is the half-life of TB500?

TB500 is reported to have a relatively long half-life of a few days.


Does TB-500 increase the production of the growth hormone?

No studies point to any link between TB4 and growth hormone production. As confirmed by mass spectrometry analysis, this synthetic peptide binds to actin to exert its effects.


Where to Buy TB 500 for Sale? is the best place to buy TB 500 online.

We have been around since 2023, supplying the highest-quality research chemicals money can buy. Our products come with a 100% satisfaction guarantee, fast shipping, and great customer service to turn every customer into a repeat customer.



TB 500 is a synthetic replica of Thymosin Beta 4, a natural peptide that occurs naturally in all blood cells. It is associated with cell motility, promotes cell survival among endothelial cells, and is a vital wound-healing agent.

Research has shown that TB 500 promotes cell migration, encourages tissue regeneration, and increases the formation of new blood vessels. This synthetic peptide has also been found to promote wound healing and blood cell reproduction. sells TB 500 for laboratory research use only.


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