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Stenabolic (SR-9009)


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SR9009 has been proven to improve cardiovascular endurance and heart health in animal studies. Preclinical investigations have reported that SR9009 stimulated fat loss, reduced inflammation, and improved cholesterol profile in mice.

Data from cell-based studies suggest that Stenabolic is highly effective against specific small lung cancer cells. Additionally, this research chemical has been found to reduce the build-up of fat, cholesterol, and other substances in the arteries of mice.


What is SR9009?

SR9009, also known as Stenabolic, is a synthetic REV-ERB agonist. REV-ERBs are proteins that regulate the circadian rhythms or the body’s internal 24-hour clock. They also control the expression of genes involved in metabolism, inflammation, and cell differentiation.

SR9009 was initially synthesized at Scripps Research Institute in 2012. It was developed as a potential treatment for obesity, diabetes, and other metabolic disorders. In one of the first studies, SR9009 stimulated significant fat loss and weight loss in mice. [R]

Preclinical studies have shown that SR9009 may protect and recover heart health. In mice, this research compound has been shown to reduce the size of atherosclerotic plaque. Additionally, SR9009 reduced blood levels of total cholesterol and triglycerides. [R][R]

SR9009 has also shown promise against different types of cancers in animal studies. It has been found to inhibit chemo-sensitive and chemo-resistant small cell lung cancer (SCLC) cells and kill cancer cells derived from the brain, breast, colon, and other tumors. [R][R]


How does SR9009 Work?

SR9009 Stenabolic works by activating a specific REV-ERB in the body. There are two types of REV-ERB proteins in the body: REV-ERBα and REV-ERBβ. SR9009 directly binds to/activates REV-ERBα, which influences lipid and glucose metabolism [R]

Additionally, SR9009 has been found to inhibit the activity of SCN (suprachiasmatic nucleus). SCN is the body’s biological clock. It regulates the sleep-wake cycle, controls the release of hormones such as cortisol and melatonin, and influences behavior and mood. [R]


SR9009 Research

SR9009 has been the subject of several animal studies examining its effects on skeletal muscle growth, fat-storing cells, heart health, metabolic syndrome, and cancer. Here are some key findings:


1. SR9009 and Weight Loss

An animal study investigated the effects of SR9009 on three groups of mice. [R]

In the first group of mice with normal body weight, all subjects experienced weight loss after being administered SR9009 for 7 days. This weight reduction was due to significant fat loss.

In the second group of diet-induced mice, SR9009 injections for 30 days resulted in 60% higher weight loss than in control animals. In the third group of genetically obese mice, Stenabolic treatment stopped weight gain after 12 days.


2. SR9009 and Osteoarthritis

A preclinical study investigated the effects of SR9009 on normal and genetically modified mice with osteoarthritis (OA).

In both groups, SR9009 treatment induced a significant reduction in OA pain. Cartilage degeneration was also significantly reduced in mice treated with SR9009. Thus, SR9009 may be effective for treating OA-related pain and reducing joint damage associated with this disease. [R]


3. SR9009 and Heart Health

In separate animal studies, SR9009 has demonstrated effects that could boost heart health.

For instance, one study found reduced triglyceride and total cholesterol levels in mice who were treated with this REV-ERB agonist for 7 to 10 days. Another study reported the same effects and a reduction in LDL ‘bad’ cholesterol in mice on a high-cholesterol diet. [R][R]

A third study investigated the effects of SR9009 on genetically modified mice. The group under observation was susceptible to the hardening of the arteries. After seven weeks of SR9009 treatment, the size of their blood vessel lesions had greatly reduced. [R]


4. SR9009 and Cancer

SR9009 has demonstrated efficacy against different types of cancers in animal studies.

In a cell-based study, this REV-ERB agonist was found to be specifically lethal to chemo-sensitive and chemo-resistant cells associated with small-cell lung cancer (SCLC). This study indicated that SR9009 could be a novel therapeutic strategy against 1st or 2nd-line SCLC treatment. [R]

Another study showed that the possible cytotoxic effects of SR9009 might not be limited to SCLC. In this study, this REV-ERB agonist was found to be lethal to cancer cells derived from breast, colon, leukemia, and other tumor types. [R]

What is equally encouraging is that the toxic effects of SR9009 are limited to cancer cells. This research chemical exerts little to no toxic effects on normal cells at comparable concentrations. [R]


5. SR9009 and Endurance

According to an animal study, mice treated with SR9009 ran longer and covered more distance than their counterparts in the control group. In terms of running capacity, there was a difference of 50 times between treated and untreated groups of mice. [R]


6. SR9009 and Anxiety

SR9009 could exert the same anti-anxiety effects as benzodiazepine (a standard anti-anxiety medication), per results from a mice study. These effects were observed in mice who were administered SR9009 (twice a day) for 3 to 10 days. [R]


Frequently Asked Questions

Is SR9009 a SARM?

In contrast to what is widely believed, SR9009 is NOT a selective androgen receptor modulator (SARM). Instead, it is a REV-ERBα agonist that is currently being investigated as a potential treatment for metabolic disorders such as obesity and type-2 diabetes.


What is SR9009 used for?

SR9009 has no clinical uses. It is not approved for human consumption by the FDA and is on the World Anti-Doping Agency’s (WADA’s) list of prohibited drugs. Research Chems sells SR9009 for laboratory research use only.


Is SR9009 a fat burner?

According to the first-ever study conducted on this research chemical, SR9009 stimulated fat loss by increasing the metabolic rate of the muscle. However, in the absence of clinical studies, it cannot be claimed that SR9009 would exert the same effect on humans. [R]


What are the side effects of SR9009?

In the absence of human studies, the side effects of SR9009 remain unknown. More research is needed to fully explore and understand this research chemical’s safety profile.


Does SR9009 make you lose weight?

Although no clinical study has been conducted on SR9009, it has stimulated significant weight loss in several animal studies. In one study, mice who were injected with SR9009 for 30 days experienced a 60% higher weight loss than control animals. [R]


Does SR9009 suppress testosterone?

In a cell-based study, SR9009 augmented testosterone production by increasing the expression of multiple genes involved in the production of steroid hormones (steroidogenic genes). Clinical studies are needed to verify whether the same effect will occur in humans. [R]


Where to Buy SR9009 for Sale?

Research Chems is the best place to buy SR 9009 Stenabolic online.

We have been around since 2023, supplying the highest-quality research compounds money can buy. Our products come with a 100% satisfaction guarantee, fast shipping, and great customer service to turn every customer into a repeat customer.



SR9009 is a synthetic REV-ERB agonist that has been shown to reduce blood cholesterol levels, regulate lipid profile, and influence circadian rhythm in animal studies. This research chemical has also stimulated weight loss, boosted heart health, and demonstrated efficacy against various types of cancer in preclinical studies. Research Chems sells SR9009 for laboratory research purposes only.


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