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Melanotan 2



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Melanotan 2 is a synthetic peptide analog of the naturally occurring hormone melanocortin, which regulates skin pigmentation. In clinical studies, it has demonstrated the ability to stimulate melanin production therefore inducing skin tanning.

Research has further shown that Melanotan 2 may stimulate erections in men with erectile dysfunction. The peptide has also been found to promote lean body mass, curb hunger, and minimize addictive/compulsive behavior in studies.


What is Melanotan 2?

Melanotan 2 is a synthetic peptide that was initially synthesized at the University of Arizona in the 1990s. It was originally developed as a potential treatment for erythropoietic protoporphyria, a rare genetic disorder that causes extreme sensitivity to sunlight.

MT-II is similar in structure to a natural hormone called alpha-melanocyte-stimulating hormone (α-MSH). Alpha-MSH plays a crucial role in regulating the production of melanin, a pigment that gives color to the skin, eyes, and hair. Alpha-MSH also suppresses appetite.

In clinical trials, Melanotan 2 has also demonstrated the ability to stimulate melanin production and therefore induce skin tanning. Additionally, this synthetic peptide hormone has been found to encourage penile erections in men with erectile dysfunction (ED). [R][R]

Research has further shown that Melanotan II may enhance sexual function and arousal levels in females. In preclinical studies, MT-II has exhibited the potential to improve autism-like behavior, induce weight loss, and improve glucose tolerance and insulin sensitivity. [R][R]

It’s worth noting that Melanotan II isn’t approved for human consumption by the FDA. This synthetic peptide is only available for laboratory and research use.


How Does Melanotan II Work?

Melanotan 2 works by binding to melanocortin receptors (MCRs) in the body. MCRs are a group of G protein-coupled receptors (GPCRs) found in the skin, brain, and adrenal glands. They play vital roles in skin pigmentation, controlling appetite, and regulating sexual behavior.

Among the 5 MCRs in the body, Melanotan II has a strong binding affinity to:

  • MC1R – Regulates melanin production and, therefore, skin, hair, and eye color [R]
  • MC3R – Adjusts food intake, body weight, and energy homeostasis [R]
  • MC4R – Regulates sexual function, including the initiation of puberty and sexual behavior [R]
  • MC5R – Implicated in the secretion of sweat, saliva, gland, etc. [R]


Melanotan 2 Research

Over the years, numerous clinical and preclinical studies have been conducted to investigate the potential effects of Melanotan II. These studies have primarily examined the impact of this synthetic peptide on melanin production, sexual dysfunction, weight loss, autism, and more.

Here are the key findings:


1) Melanotan 2 and Erectile Dysfunction

Multiple human studies have examined the erectogenic properties of Melanotan II.

In a placebo-controlled crossover study, MT-II treatment stimulated erections in 8 out of 10 males with psychogenic erectile dysfunction. Psychogenic ED is when a person can achieve normal erections during sleep but not when they are awake. [R]

Another placebo-controlled study found that Melanotan II treatment stimulated penile erections in 17 out of 20 men with ED. All the test subjects had psychogenic and organic ED. Nausea and yawning were frequently reported side effects. [R]


2) Melanotan 2 and Tanning

Melanotan II has demonstrated tanning activity in several studies.

For instance, in the first study cited above, at least one patient reported increased skin pigmentation after receiving 0.1 mg/kg MTII. Another study showed that two volunteers had increased pigmentation in the face, upper body, and buttocks 1-week after MT-II treatment ended. [R]

Both the human studies were conducted after MT II had exhibited tanning activity in animals. Before either study was conducted, a study involving a light-colored German shepherd dog found that a 3-week MT-II treatment changed the animal’s coat color from yellow-tan to black. [R]


3) Melanotan 2 and Female Sexual Desire

A 2004 study reports that MT-II can not only enhance sexual function in males. This melanocortin analog can also enhance levels of sexual desire and genital arousal in females. [R]

That is because unlike other sexual enhancement drugs whose benefits are limited to males, MT-II acts on the level of the central nervous system. This mechanism of action could help Melanotan II elicit a rather natural sexual response.


4) Melanotan 2 and Weight Loss

In an animal model, Melanotan II treatment triggered fat and weight loss. [R]

Per qualified professionals conducting the study, MT-II triggered both the above effects by stimulating the brain’s melanocortin system. It was also noted that this synthetic peptide produced a long-lasting weight loss without the need of maintaining diet restriction.

In other words, MT-II triggered weight loss independent of dieting or exercising. Additionally, the research chemical reduced the animals’ abdominal fat pads by 40 percent.


5) Melanotan 2 and Diabetes

According to separate preclinical studies, MT-II could improve glucose tolerance and increase insulin sensitivity. [R][R]

High insulin sensitivity reduces blood sugar levels by helping your body use blood glucose more effectively. An improved glucose tolerance (the rate of glucose’s clearance from the blood) plays a key role in keeping your blood sugar levels normal.


6) Melanotan 2 and Autism

In a mouse model of autism, MT-II reversed autistic features.

Specifically, this synthetic peptide was found to improve the autistic mice’s sociability indices. This suggests that MT-II may be effective in improving social deficits associated with ASD. However, long-term human studies are needed to verify this. [R]


7) Melanotan 2 and Alcohol Abuse

Results from a preclinical study show that MT-II treatment reduced voluntary alcohol consumption in mice. It was reported that these protective effects (vis-à-vis binge ethanol drinking) were driven by MT-II binding to MC3R in the brain. [R]

There is evidence to suggest that MC3R may play a role in alcohol consumption and alcohol addiction. Studies in mice have shown that MC3R knockout mice (mice that lack the MC3R gene) have reduced alcohol intake and preference compared to wild-type mice.


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Frequently Asked Questions

Is Melanotan II a steroid?

Melanotan 2 is a synthetic analog of α melanocyte stimulating hormone, a natural hormone that stimulates the production of melanin and increases sexual desire.


What is the half-life of Melanotan II?

Animal studies have reported that Melanotan II has a half-life of 1.5 to 2 hours. This means it might not remain in the bloodstream for an extended period.


What is Melanotan II used for?

Melanotan II isn’t approved for any clinical use by the FDA. It can only be used for laboratory and research purposes.



Melanotan II is a synthetic peptide that is similar in structure to a natural hormone. In studies carried out on humans, it has demonstrated the ability to induce tanning, stimulate penile activity, and enhance sexual desire/genital arousal. However, it isn’t approved by the FDA.


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