Buy Ligandrol (LGD-4033) for Sale
Ligandrol LGD-4033 is a selective androgen receptor modulator (SARM) that is under investigation as a possible treatment for cancer-related weight loss and various other conditions. It is considered a research chemical and is not approved for human use by the FDA.
In a 2013 clinical trial, Ligandrol was reported to increase muscle mass in healthy young men. A 2018 human study showed that people aged over 65 who were recovering from a hip fracture significantly increased their muscle mass after taking Ligandrol.
What is Ligandrol?
Ligandrol, also known as LGD-4033, is a type of selective androgen receptor modulator (SARM). It is currently being investigated for its potential therapeutic use in conditions such as cancer-related muscle wasting, osteoporosis, and other musculoskeletal disorders.
Ligandrol was initially developed by the company Ligand Pharmaceuticals in the United States. However, it is currently being developed and marketed by Viking Therapeutics, which acquired the rights to develop and market LGD-4033 from Ligand Pharmaceuticals in 2014.
Results of the first human trial on Ligandrol were published in 2013. They showed that LGD-4033 helped healthy young men gain muscle mass without putting on muscle mass. LGD-4033 administration was also associated with dose-dependent testosterone suppression. [R]
A 2018 study examined the effects of Ligandrol on people aged over 65 who were recovering from a hip fracture. It was reported that patients who took LGD-4033 gained muscle mass. Reportedly, the LGD-4033 group could walk further than patients not on the drug. [R]
How does Ligandrol Work?
Ligandrol (LGD-4033) works by selectively binding to androgen receptors in the body, particularly those found in bone and muscle tissue. Androgen receptors are a type of protein that regulate the development and maintenance of male characteristics. [R]
Research has shown that LGD-4033 has robust selectivity for muscle versus prostate. This enables it to stimulate anabolic activity (muscle growth) in muscle tissues, while side-stepping the androgenic effects that are commonly associated with traditional anabolic steroids. [R]
Ligandrol has been the subject of several clinical trials and preclinical studies. All these investigations have explored its potential effects on lean muscle mass, bone mineral density, intramuscular fat content, and other parameters.
1) Ligandrol and Lean Body Mass
Two clinical trials have shown that LGD-4033 may increase lean muscle mass.
In the first investigation, 76 healthy men were randomized to a placebo or different doses of Ligandrol for three weeks. Results showed that LGD-4033 produced significant gains in lean body mass. Notably, no drug-related serious adverse events were reported. [R]
The second trial was a phase-2 placebo-controlled study in which patients who had recently suffered a hip fracture were required to receive either LGD-4033 or a placebo. Findings demonstrated a dose-dependent increase in lean body mass after 12 weeks. [R]
2) Ligandrol and Bone Density
Data from preclinical studies suggest that LGD-4033 may positively impact bone density.
In a 2009 study conducted by Ligand Pharmaceuticals, Ligandrol reportedly increased bone mineral density (mineral content in a given area of bone tissue) in osteopenic female rats The greatest increase was observed in cortical bone. [R]
LGD-4033 was found to increase bending strength (an indicator of resistance to fracture) in the same study. This suggests that LGD-4033 can potentially reduce the risk of fall-related bone fractures.
3) Ligandrol and Fat Mass
LGD-4033 may stimulate a dose-dependent decrease in mean fat mass.
This was shown in the above phase 2 clinical trial in which patients who took Ligandrol for 12 weeks experienced a dose-related decrease in the average amount of fat in the body. [R]
4) Ligandrol and Triglycerides
Health experts are unanimous that high levels of triglycerides in the blood are a risk factor for heart disease. Triglycerides can contribute to the buildup of plaque in the arteries, which can lead to strokes and heart attacks.
In the above phase 1 clinical trial, LGD-4033 produced a decrease in triglyceride levels across all doses (0.1 mg, 0.3 mg, and 1 mg). However, the reduction wasn’t dose-dependent. The highest decrease (24 mg/dL) was observed among the 0.3 mg group. [R]
5) Ligandrol and Leg Press Strength
Leg press strength is an excellent indicator of lower body strength.
A placebo-controlled study investigated the effects of LGD-4033 on leg press strength. At the 1.0 mg dose, the increase in strength averaged 68.3 N. The participants’ stair-climbing speed and power, two more indicators of lower body strength, revealed a trend toward dose-related improvement. [R]
Frequently Asked Questions?
Is it illegal to buy LGD-4033?
It depends on the country you live in. In some countries, LGD-4033 is classified as a Schedule III drug and is illegal to buy without a prescription, while in other countries, it is legal to purchase for research purposes. In the USA, it is 100% legal to buy LGD-4033 for laboratory and research use.
Does LGD-4033 affect liver?
At least two case studies have shown that LGD-4033 may cause liver toxicity.
The first case study described a 32-year-old man with elevated liver enzymes and jaundice after taking LGD-4033 daily for two weeks. In the second study, two young men were hospitalized with liver injury after using Ligandrol and/or Ostarine for a few weeks. [R][R]
What is the half-life of LGD-4033?
The half-life of LGD-4033 is approximately 24-36 hours. This means that it takes around one to two days for the concentration of LGD-4033 in the bloodstream to be reduced by half.
Does LGD-4033 lower testosterone?
Results from the first clinical study show that LGD-4033 dose-dependently suppressed total testosterone and sex hormone-binding globulin levels from baseline to day 21. The suppression of total testosterone was found to be greater than that of free testosterone.
What are the negatives of LGD-4033?
Some of the negatives of LGD-4033 include potential liver damage, suppression of endogenous testosterone production, and the risk of other side effects such as nausea, headaches, and fatigue.
Does LGD-4033 increase stamina?
According to a 2018 clinical study, patients recovering from a hip fracture were able to walk 20 meters longer after taking LGD-4033 than those not on the drug. [R]
A separate 21-day trial showed that LGD-4033 administration produced dose-dependent gains in leg press strength, which is significant as enhanced leg press strength is an indicator of increased endurance. [R]
Where to Buy LGD 4033 for Sale?
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Ligandrol is a non-steroidal SARM that has been investigated as a potential treatment for cancer-related muscle loss and other musculoskeletal disorders.
Various clinical trials conducted over the years have shown that it may increase lean body mass and lower body fat mass. Preclinical studies have highlighted other positive effects, including increased bone mineral density and enhanced fracture resistance. However, it’s not approved for human consumption.
Research Chems sells Ligandrol for laboratory research use only.