Buy KPV for Sale
KPV is a peptide with potent anti-inflammatory properties. Animal research has shown that it can speed wound healing, fight intestinal inflammation, and induce scar reduction following surgery. KPV is shown to be safe when given orally, topically, or subcutaneously.
Although it’s derived from alpha-melanocyte-stimulating hormone (alpha-MSH), KPV isn’t as potent and doesn’t cause skin pigmentation, one of the major side effects of alpha-MSH. In animal studies, KPV exerted stronger anti-inflammatory effects than alpha-MSH.
What Is KPV?
KPV is a tripeptide (made up of three amino acids) with anti-inflammatory properties. It is the C-terminal fragment of the alpha-melanocyte-stimulating hormone. Alpha MSH is a natural hormone that fights inflammation and mediates pigmentation and sexual behavior.
Research shows that the anti-inflammatory effects of alpha-MSH are mediated by three amino acids found in the N-terminal of its chain. These amino acids are lysine-proline-valine (KPV). Reportedly, KPV peptide can fight inflammation more potently than its parent hormone. [R]
In two animal models of inflammatory bowel disease (IBD), treatment with KPV led to improvement in the disease’s symptoms. This potent anti-inflammatory peptide was found to induce earlier recovery, regain body weight, and reduce pro-inflammatory changes. [R]
Several studies showcase how KPV and other alpha-MSH derivatives affect wound healing. These peptides expedite healing, reduce inflammation, and improve cosmetic outcomes. The results are similar to those achieved with other anti-inflammatory medications. [R]
How Does KPV Work?
Research shows that KPV exerts its anti-inflammatory effects by suppressing TNF-alpha, NF-kappaB, and mitogen-activated protein kinase (MAPK) activity. TNF-alpha is a pro-inflammatory cytokine whose increased levels in the body lead to enhanced inflammation.
Nuclear Factor KappaB is a transcription factor whose activation leads to increased inflammation in the body. Some MAPKs are also involved in inflammatory signaling pathways. Their activation leads to the production of pro-inflammatory mediators in the body.
Human studies on KPV are lacking. Multiple preclinical studies have examined its impact on wound healing, chronic inflammation, and scar formation. The effects of hyaluronic acid-functionalized nanoparticles loaded with KPV on ulcerative colitis have also been examined.
Here are the key findings:
1) KPV and Intestinal Inflammation
Several preclinical studies show that KPV can be effective against IBD
In a cell-based study, human intestinal cells were administered pro-inflammatory cytokines to create conditions similar to inflammatory bowel disease. Afterwards, these cells were treated with KPV to investigate whether this synthetic peptide attenuated IBD. [R]
Results from this preclinical study show that KPV exerted several anti-inflammatory effects. It inhibited the activation of many inflammatory pathways and reduced the secretion of pro-inflammatory cytokines. This suggests a possible therapeutic role for KPV against IBD. [R]
Another study examined whether the loading of KPV onto functionalized hyaluronic acid nanoparticles can be effective against IBD. Reportedly, this combo alleviated inflammation and accelerated mucosal healing. Oral treatment was more effective than other modes. [R]
2) KPV and Fever
Multiple animal studies show that KPV is a powerful antipyretic (fever reducer).
A 1984 study examined whether alpha-MSH could reduce fever in rabbits. All the animals were given an artificial fever by the IV administration of leukocytic pyrogen (LP). The human LP is a small endogenous protein that mediates fever in the body. [R]
Results from the study show that alpha-MSH reduced fever after 0.5 – 2.0 mg and 2 – 200 mg doses. The researchers noted that the KPV part was crucial for antipyretic activity. However, the fever-reducing potency of KPV was lower than that of full alpha-MSH. [R]
3) KPV and Wound Healing
Wound healing is a crucial process divided into three different phases. These include inflammatory, proliferative, and remodeling. [R]
Animal research shows that KPV can be crucial in all three phases. For instance, this peptide has demonstrated its anti-inflammatory effects in vitro and in vivo. It can reduce the activity of pro-inflammatory cytokines and inhibit inflammatory signaling pathways. [R][R]
Similar to its role in the first stage, KPV may also be involved in the remaining two. This peptide has been found to reduce chronic inflammation that leads to hypertrophic scar formation. This scar develops during the proliferative phase of the healing process. [R]
Lastly, KPV may expedite the remodeling of the damaged site by increasing collagen production. It could do that by suppressing the secretion of IL-8. Increased collagen formation strengthens the healing tissue, helping restore its structural integrity. [R]
Where to Buy KPV for Sale?
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Frequently Asked Questions
What is the half-life of KPV?
KPV has a very short half-life of a few minutes.
What is the benefit of KPV peptide?
KPV is a potent anti-inflammatory peptide with wound healing and antipyretic (fever) properties. However, in the absence of human studies, it’s only available for laboratory research use.
KPV is a natural peptide isolated from the C-terminal of the alpha-melanocyte-stimulating hormone. Animal studies show that it’s less potent than alpha-MSH with fewer side effects. Preclinical studies further show that this peptide can fight inflammation and expedite the wound-healing process.