Buy Ipamorelin for Sale
Ipamorelin is a synthetic growth hormone secretagogue, meaning it enhances the production and release of growth hormone. At the same time, it has been shown to cause weight gain, enhance insulin secretion, and increase bone mineral density in animals.
Ipamorelin has also been found to increase the production of insulin-like growth factor 1, or IGF1. Additionally, Ipamorelin could counteract the catabolic (metabolizing) effects of corticosteroid medications on skeletal muscle and bones.
What is Ipamorelin?
Ipamorelin is a synthetic peptide made up of five amino acids. It is capable of stimulating the release of growth hormone (GH) from the pituitary gland. Research has shown that its selectivity for GH is similar to that of growth hormone-releasing hormone, a natural hormone. [R]
Ipamorelin was initially developed by Novo Nordisk in the late 1990s. Later on, it was investigated in clinical trials as a possible treatment for postoperative ileus or PI. PI is a condition in which the bowel stops functioning regularly following surgical procedures. [R]
Various preclinical studies have also been conducted to examine its effects. These studies have shown that Ipamorelin could cause weight gain in GH-deficient subjects. This selective growth hormone secretagogue could also increase bone mineral density. [R]
Ipamorelin has also been found to counteract the catabolic effects of corticosteroids. Corticosteroids are medications used to reduce inflammation and suppress the immune system. However, their overuse may reduce protein synthesis, leading to muscle atrophy. [R]
How does Ipamorelin Work?
Ipamorelin works by mimicking the actions of ghrelin in the body. Ghrelin is a gut hormone that stimulates GH release from the pituitary gland. Ipamorelin binds to the ghrelin receptor in the hypothalamus to stimulate GH release from the pituitary.
Ipamorelin’s working mechanism distinguishes it from other growth hormone secretagogues (GHSs), such as Sermorelin, which stimulate GH release via another pathway. Another difference between Ipamorelin and other GHS is that it’s more selective in action. [R]
Unlike other GHSs, Ipamorelin doesn’t significantly raise the plasma levels of cortisol and adrenocorticotropic hormone (ACTH). Neither does it affect follicle-stimulating hormone (FSH), luteinizing hormone (LH), or thyroid-stimulating hormone in the body. [R]
This shows that the selectivity ghrelin mimetic Ipamorelin displays for GH-release is similar to the one on offer by GHRH.
While Ipamorelin and diabetes research has received huge press attention over the years. This GH secretagogue has also been investigated for its potential effects on bone mineral density, weight gain, postoperative ileus, and other conditions. Here are the key findings:
1) Ipamorelin and Bone Health
In a study involving adult female rats, Ipamorelin and a growth hormone-releasing peptide increased bone mineral content (BMC). BMC refers to the number of minerals in bones. A high BMC is an indicator of strong bones and a lower risk of developing a fracture. [R]
Another preclinical study established a link between Ipamorelin and longitudinal bone growth rate (LGR), which refers to the rate at which bones grow in length over time. The study showed that the higher the dose of Ipamorelin, the bigger the LGR. [R]
2) Ipamorelin and Weight Gain
Ipamorelin has been shown to induce body weight gain in normal and GH-deficient rats.
According to an animal study, GH-deficient rats who were administered Ipamorelin and GH experienced a significant increase in body intake. Interestingly, the fat gain was GH-independent. Instead, it was induced by an increase in the animals’ food intake. [R]
After noting this effect, researchers then administered Ipamorelin to normal rats. Once again, an increase in overall body weight vis-à-vis baseline values was observed. That, too, within only two weeks of treatment.
3) Ipamorelin and Diabetes
Ipamorelin may lower blood glucose levels by stimulating insulin secretion.
This was observed in a study involving normal and diabetic rats. Both groups experienced significant increases in insulin secretion following Ipamorelin administration. [R]
Researchers conducting the study hypothesized the likely mechanism behind this effect. They stated that it was likely that Ipamorelin increased insulin production by stimulating the cells where insulin is produced and stored. However, more studies are needed to verify this. [R]
4) Ipamorelin and Corticosteroids
Ipamorelin has been shown to counter muscle weakness caused by corticosteroids.
Corticosteroids are naturally occurring hormones that help the body fight inflammation. They are also used as medications to reduce inflammation and suppress the immune system. However, their overuse or prolonged use may lead to muscle weakness.
In an in vivo rat model, the reduction in muscle strength caused by corticosteroids was reversed by Ipamorelin treatment. [R]
5) Ipamorelin and Postoperative Ileus
Ipamorelin has undergone trials as a potential treatment of postoperative ileus, a condition in which the bowel stops regular functioning after surgery. However, due to the lack of efficacy, the trials were abandoned at an early stage. [R]
Is Ipamorelin a steroid?
Ipamorelin is a synthetic growth hormone secretagogue that raises growth hormone levels in the body.
What is the half-life of Ipamorelin?
Ipamorelin is reported to have a half-life of 2 hours.
Does Ipamorelin increase lean body mass?
There is no evidence to suggest that Ipamorelin could increase lean body mass.
Where to Buy Ipamorelin for Sale?
Research Chems is the best place to buy Ipamorelin for sale.
We have been around since 2023, supplying the highest-quality research compounds money can buy. Our products come with a 100% satisfaction guarantee, fast shipping, and great customer service to turn every customer into a repeat customer.
The growth hormone secretagogue Ipamorelin has been shown to induce weight gain, prevent muscle wasting, and strengthen bones in animal studies. However, at the time of writing, clinical studies are yet to examine this growth hormone secretagogue’s effects on humans.
Research Chems sells Ipamorelin for laboratory and research use only.