Buy IGF-1 LR3 for Sale
IGF-1 LR3 is a lengthened analog of human insulin-like growth factor 1. Research shows that it lowers blood sugar levels by improving glucose uptake, boosts gut health, and enhances libido by increasing the secretion of inhibin-A and progesterone.
IGF-1 LR3 remains active in the bloodstream for up to 120 times longer than IGF-1. This results in an enhanced half-life and increased activity. Recent research suggests that it may increase muscle hypertrophy and repair by inhibiting myostatin.
What is IGF-1 LR3?
IGF-1 LR3 (Insulin-like Growth Factor 1 Long Range 3) is a synthetic analog of the naturally occurring insulin-like growth factor 1 (IGF-1). Research shows that it is much more potent than IGF-1, with a longer half-life and increased activity in the bloodstream. [R]
Animal studies show that IGF-1 LR3 lowers blood sugar levels by increasing glucose uptake in adipocytes (fat cells). It has also been shown to promote cell division, increase fat metabolism, and inhibit myostatin, a hormone that hinders muscle repair and hypertrophy. [R]
IGF-1 LR3 has also demonstrated the ability to increase gut growth in animal studies. It has also been reported to improve maternal lactation in a female mice model and could stabilize atherosclerotic plaque to lower the risk of heart attack, stroke, and heart disease. [R]
A 2022 animal study reports that IGF-1 LR3 could increase the secretion of inhibin A and progesterone. Inhibin is a hormone that regulates sperm production in males and the menstrual cycle in females. Progesterone helps maintain pregnancy and affects mood. [R]
How Does IGF-1 LR3 Work?
IGF-1 LR3 works by mimicking the actions of IGF-1 in the body. It binds to IGF-1 receptor sites to stimulate cell division, growth, and proliferation. Due to structural differences between the two (explained below), IGF-1 LR3 interacts more strongly with receptors than IGF-1.
However, unlike the peptide hormone from which it is derived, IGF-1-LR3 has a very low affinity for the IGF-binding proteins (IGFBPs) in the body. This enables it to last and act much longer in the bloodstream, as the IGFBPs render the natural IGF-1 inactive. [R]
IGF-1 Vs IGF-1 LR3
IGF-1 LR3 was synthesized by making two changes to the structure of IGF-1. The first is that it possesses an arginine instead of a glutamic acid at the 3rd position in the amino acid sequence. Another was the addition of 13 amino acids to the N-terminus. [R]
These changes are the reason why IGF-1 LR3 exhibits improved metabolic stability than the hormone from which it is derived. They are also why this synthetic peptide is more potent, has a longer half-life, and has a low binding affinity for IGF-1 binding proteins. [R]
Compared to IGF-1, which has a half-life of about 12-15 hours, IGF-1 LR3 possesses a significantly longer half-life of about 20-30 hours. This means this peptide will last longer in the bloodstream and exert its effects for a considerably extended period. [R]
IGF-1 LR3 Research
Multiple animal and cell-based studies have examined the potential effects of IGF-1 LR3. These studies have mainly examined its impact on cell division and proliferation, gut growth and repair, and glucose uptake. Here are the key findings:
1. IGF-1 LR3 and Inhibin A
Inhibin A is a protein hormone that plays a role in reproductive biology, particularly in the regulation of the female menstrual cycle and the male reproductive system. Its secretion is stimulated by follicle-stimulating hormone (FSH) and luteinizing hormone (LH).
An animal study has shown that IGF-1 LR3 enhanced LH- and FSH-induced secretion of Inhibin A. These data demonstrate that IGF-1 LR3 may have potential implications on pregnancy, sexual desire, and conception, all of which are influenced by inhibin A. [R]
2. IGF-1 LR3 and Cell Division
Various preclinical studies show that IGF-1 LR3 is a potent growth factor for encouraging cell growth, division, and proliferation. [R]
While IGF-1 also exerts these effects, there is one key difference. Unlike its parent peptide, the above effects of IGF-1 LR3 aren’t limited to bone and new muscle cells. This synthetic peptide also encourages cell division in the skin, kidney, liver, blood, and nerve tissues.
3. IGF-1 LR3 and Myostatin
Myostatin is a peptide hormone that restricts muscle growth (hypertrophy) and repair. Its inhibition could thus lead to the enlargement of muscle fibers.
In an in-vivo study, IGF-1 LR3 treatment inhibited myostatin levels and reduced adiposity (obesity). However, it also encouraged adipogenesis, or the formation and development of fat cells, suggesting that myostatin keeps fat levels in check. [R]
4. IGF-1 LR3 and Glucose Uptake
Research shows that IGF-1 LR3 increases glucose uptake from the blood by the liver, nerve, and muscle cells to lower blood sugar levels. [R]
This effect is reportedly followed by the breakdown of glycogen and triglycerides in the body, leading to an overall decrease in energy availability. That, in turn, gives way to the environment of net catabolism or in which more energy is consumed than produced.
5. IGF-1 LR3 and Gut Growth
Thanks to emerging evidence over the past two decades, it is clear that a healthy gut is essential for a healthy immune system, brain, and heart. Recent research has also linked a well-functioning gut with better mood and improved sleep quality.
A 1992 study examined whether IGF-1 and IGF-1 LR3 encouraged gut growth in 150g dexamethasone-treated rats. Final results showed a significant growth in all regions of the gut, including the stomach, small intestine, and colon. [R]
6. IGF-1 LR3 and Heart Health
Atherosclerosis is a heart disease characterized by the build-up of plaque, a mixture of fats, cholesterol, and other substances in artery walls. If allowed to fester, this plaque can restrict blood flow to the heart, causing heart attack or stroke.
Results from a cell-based study show that this potent growth factor (IGF-1 LR3) can stabilize atherosclerotic plaque. It could reportedly do that by altering the characteristics of smooth muscle in the heart, potentially improving heart health. [R]
7. IGF-1 LR3 and Lactation
According to results obtained from a maternal mice model, treatment with IGF-1 LR3 enhanced lactation from the mammalian cell culture. This effect suggests that this synthetic peptide may help improve lactation among new mothers. [R]
Frequently Asked Questions
Is IGF-1 LR3 an anabolic steroid?
IGF-1 LR3 is a synthetic analog of insulin-like growth factor 1. IGF-1 is the most potent growth factor found in the human body. It mediates the effects of growth hormone.
What does IGF-1 LR3 do?
No human studies have examined the effects of IGF-1 LR3. Animal studies show that this synthetic peptide can improve heart health, increase lactation, and improve cell division. It has also been shown to protect muscle cells and is implicated in regulating cell growth.
Where to Buy IGF-1 LR3 for Sale?
ResearchChems.org is the best place to buy IGF-1 LR3 for sale.
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IGF-1 LR3 is a synthetic analog of IGF-1 with a higher potency, half-life, and activity in the bloodstream. It has been found to inhibit cell death, promote cell division, and encourage lactation. This synthetic peptide has also been found to exert growth-promoting effects relative to the gut.
ResearchChems.org sells IGF-1 LR3 for laboratory and research use only, not for human consumption.