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Ibutamoren (MK-677)


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Buy MK-677 (Ibutamoren) for Sale

MK 677, also known as Ibutamoren, is a growth hormone secretagogue developed to stimulate the production of growth hormone (GH) and insulin-like growth factor 1 (IGF-1). Studies have shown that it can increase GH and IGF-1 levels without serious side effects.

Studies have shown that MK 677 has potential benefits such as increased muscle mass, improved bone density, and enhanced sleep quality. This GH secretagogue has also been shown to reverse diet-induced catabolism and reduce fat mass in human studies.

Research Chems sells MK 677 for laboratory research only.


What is MK 677

MK 677 is a growth hormone secretagogue developed by the pharmaceutical company Amarin. It was originally developed to treat growth hormone deficiency in children and adults. Studies have shown that it can successfully increase GH levels in GH-deficient adults.

Several studies have been conducted on the potential benefits of MK 677. In a randomized, double-blind, placebo-controlled trial, Ibutamoren was found to successfully increase lean body mass in healthy young adults by an average of 1.8 kg over a 12-month period. [R]

MK 677 has also been studied for its potential use in treating conditions such as growth hormone deficiency, osteoporosis, and cachexia (muscle wasting). In a small study of 24 healthy obese males, it increased lean body mass and basal metabolic rate. [R]

Another study found that MK 677 improved sleep quality and REM sleep in healthy young men. It also increased levels of IGF-1 and without having any effect on the stress hormone cortisol. It’s important to note that all these studies have several limitations. [R][R]


How does MK 677 Work?

MK 677 works by stimulating the production of growth hormone and insulin-like growth factor 1 (IGF-1). It does this by binding to the ghrelin receptor. In addition to stimulating GH release, ghrelin is responsible for regulating appetite, food intake and energy balance. [R]

When Ibutamoren binds to the ghrelin receptor, it stimulates the release of growth hormone from the pituitary gland. This leads to an increase in the production of IGF-1, which is responsible for promoting cell growth, differentiation, and regeneration. [R]

Multiple preclinical studies and clinical trials have verified the above effects. For example, one study involving GH-deficient adults reported an increase in mean GH concentrations by 79 +/- 19% following 4-week treatment with this GH secretagogue. [R]


MK 677 Research

Studies have shown that MK 677 increases growth hormone levels, lean muscle mass, bone density, and alleviates cachexia and sarcopenia symptoms. Additionally, this GH secretagogue has been shown to enhance sleep quality and improve body composition.

It’s important to note that most of these studies were conducted for short-term periods only. Long-term effects of MK 677 or its complete safety profile remain unknown. [Enter brand name] sells MK 677 for laboratory research use only and not for human consumption.


1) MK 677 and Growth Hormone

MK 677 increases growth hormone levels. Several studies have shown that MK677 enhances the pulsatile release of GH in healthy young men and older men and women. These studies further report that Ibutamoren is well-tolerated after oral administration. [R][R]

Ibutamoren may also be beneficial for people with GH deficiency. For example, in a clinical trial involving children with GHD, MK 677 elicited an increase in GH and IGF-1 levels. Similar results were observed upon oral administration of Ibutamoren to GH-deficient men. [R][R]


2) MK 677 and Lean Body Mass

In a randomized, double-blind, placebo-controlled trial, MK 677 increased lean body mass in healthy elderly adults by an average of 1.8 kg over a 12-month period. This trial showed that those who received MK 677 showed a higher increase in lean body mass than members of the placebo group. [R]

In another study, 24 adults with GH deficiency were given either MK 677 or a placebo for 6 months. Those who received MK 677 significantly increased lean body mass compared to the placebo group. Moreover, bone density also increased in the MK 677 group. [R]


3) MK 677 and Cachexia

Cachexia is a condition characterized by weight loss, muscle wasting, and weakness. This condition can significantly reduce the quality of life, increased morbidity and mortality, and cause a poor response to therapy. It can occur in patients with various conditions.

MK 677 has been shown to alleviate cachexia symptoms in human studies. In a study involving 8 otherwise healthy volunteers, MK 677 treatment reversed diet-induced catabolism by improving nitrogen balance. This suggests it may be useful in treating catabolic conditions. [R]


4) MK 677 and Bone Density

In a randomized, double-blind, placebo-controlled trial, the administration of MK 677 alongside alendronate produced significant increases in bone mineral density at the femoral neck. The femoral neck is an important site for fracture prevention. [R]

In another study, healthy elderly adults were given MK 677 for a period of 2 weeks. At the end of the study, the researchers found that MK 677 significantly increased levels of a bone formation marker called osteocalcin, indicating an increase in bone turnover and improved bone health. [R]


5) MK 677 and Sleep Quality

In a small-scale clinical trial, prolonged oral treatment with MK-677 improves sleep quality in men. In younger and older adults, MK-677 treatment was associated with a 20% and 50% increase in REM sleep compared to the placebo. [R]

Aside from that, MK-677 treatment resulted in an approximately 50% increase in the duration of stage IV sleep in young patients. In addition, the frequency of deviations from normal sleep decreased from 42% under placebo to 8% under high-dose MK-677 treatment.


6) MK 677 and Sarcopenia

Sarcopenia refers to the age-related loss of muscle mass, strength, and function, which can lead to physical disability, frailty, and a decreased quality of life. It is a significant health concern among older adults, particularly those who are sedentary or have chronic diseases.

A clinical study was conducted to determine whether MK 677 could safely and effectively attenuate the symptoms of sarcopenia. This study involved frail elderly women with this condition. Final results showed a significant increase in lean body mass from baseline after month 6. [R]


Frequently Asked Questions

Is MK 677 a SARM?

No, MK 677 is a human growth hormone secretagogue. Selective androgen receptor modulators bind to androgen receptors in the skeletal muscle tissue and impact natural androgen production. In contrast, MK 677 binds to the ghrelin receptor to stimulate growth hormones production.


Is MK 677 a GHRP?

While MK 677 and growth hormone-releasing peptides (GHRPs) stimulate growth hormone release in the body, their working mechanisms differ.

For example, MK-677 bind to the ghrelin receptor in the hypothalamus and pituitary gland, while GHRPs bind to the growth hormone secretagogue receptor (GHS-R) in the pituitary gland.


What is the half-life of MK 677?

The half-life of MK 677 is approximately 24 hours.


Does MK 677 cause testosterone suppression?

MK 677 does not appear to cause testosterone suppression in healthy individuals. However, it may have a slight suppressive effect on testosterone levels in individuals with low testosterone. This is because MK 677 increases the release of GH, which in turn can stimulate the production of testosterone.


Does MK 677 cause gynecomastia?

MK 677 does not cause gynecomastia, which is the enlargement of breast tissue in males. However, it may cause temporary water retention, which can sometimes be mistaken for gynecomastia. This is because MK 677 increases levels of IGF-1, which can cause water retention.


What are the side effects of MK 677?

Several studies conducted on MK 677 have highlighted its various potential side effects. These include raised blood pressure, increased insulin resistance, heightened appetite, water retention, and more.


Where to Buy MK 677 for Sale?

Research Chems is the best place to buy MK 677 online.

We have been around since 2023, supplying the highest-quality research compounds money can buy. All of our products come with a 100% satisfaction guarantee, free shipping, and great customer service. What more can you ask for!



MK 677 is a promising research chemical that could potentially treat various conditions. However, further research is needed to examine its safety profile. Long-term studies are also required to validate the above effects. Until then, MK 677 should only be used for laboratory and research purposes.


Disclaimer: The information provided in this article is for medical purposes only and does not constitute medical advice. It is important to consult with a licensed healthcare professional before using any supplement or medication. Additionally, all the products on this website are intended for laboratory and research use only. They are not intended for human or veterinary usage.


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