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CJC-1295 DAC



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CJC-1295 is a synthetic analog of growth hormone stimulating hormone. Research has shown that it indirectly stimulates growth hormone production in the body. It has also been found to increase plasma levels of insulin-like growth factor 1 (IGF-1).

CJC-1295 exhibits a longer half-life than natural GHRH. That is because of the addition of a drug affinity complex (DAC) to the peptide’s chain, which has increased its bioavailability and made CJC-1295 more resistant to degradation by enzymes in the body.


What is CJC-1295?

CJC-1295 is a synthetic peptide hormone derived from the body’s growth hormone-releasing hormone (GHRH). It stimulates the GHRH receptors in the pituitary to increase the release of growth hormone, which is vital for normal growth, development, and metabolism.

Research has shown that CJC-1295 has a higher bioavailability and a longer half-life than natural GHRH. This synthetic peptide takes 1-4 hours to reach peak concentrations in the bloodstream with an estimated half-life of 5.8-8.1 days. In contrast, GHRH has a half-life of 7 minutes. [R]

Clinical studies have reported that CJC-1295 stimulates dose-dependent increases in plasma GH and IGF-1 levels. In preclinical studies, this synthetic peptide has demonstrated the ability to normalize growth. CJC-1295 is currently undergoing investigations as a potential sleep enhancer. [R]


How Does CJC-1295 Work?

CJC-1295 works by stimulating the GHRH receptors in the pituitary gland to increase the release of GH and IGF-1. Research has shown that a single injection of CJC-1295 could increase mean plasma GH and IGF-1 concentrations by 2-10 fold and 1.5-3 fold, respectively. [R]

CJC-1295 has been found to work for longer periods in the body than GHRH. This is because of the addition of the drug affinity complex. The addition of DAC allows covalent binding of CJC-1295 with DAC to natural albumin, extending its half-life to a duration similar to that of albumin. [R]

It isn’t just natural GHRH that has a smaller half-life than CJC-1295. Various other growth hormone secretagogues also last less long in the body. Examples include Sermorelin (half-life of 11-12 minutes) and growth hormone-releasing factor (GRF), which has a half-life of a few minutes. [R]


CJC-1295 Research

Multiple clinical and preclinical studies have examined the potential effects of this selective growth hormone secretagogue. These studies have mainly examined the effects of this synthetic peptide on mean plasma growth hormone levels, IGF-1 concentrations, and GH deficiency.

Here are the key findings:


1) CJC-1295 and Growth Hormone

Various studies have shown that CJC-1295 could increase GH levels in the body.

In a double-blind, placebo-controlled trial, a single injection of CJC-1295 increased mean plasma growth hormones by 2- to 10-fold for 6 days. Pulsatile secretion of growth hormone (GH) persisted during continuous stimulation by CJC-129 [R]

Another human study reported similar results. The investigation found that serum levels of GH (both mean and lowest) in the 11 subjects showed significant increases one week after the administration of CJC-1295. No serious adverse events were reported in both studies. [R]


2) CJC-1295 and Insulin-like Growth Factor 1

In the above studies, an increase in IGF-1 levels was also reported.

The first study reported an increase in mean plasma IGF-1 concentrations by 1.5 to 3-fold. It was further indicated that the IGF-1 levels remained elevated for 9-11 days after a single dose. After multiple CJC-1295 doses, IGF-1 levels remained above baseline for 28 days. [R]

In the second investigation, serum levels of IGF-1 showed significant increases seven days after administration of CJC-1295. Both studies were thus able to point to a potential dose-dependent relationship between CJC-1295 and IGF-1 levels in the body.


3) CJC-1295 and Growth Hormone Deficiency

Growth hormone deficiency (GHD) is a condition characterized by a lack of normal growth and development.

In an animal model of GHD, CJC-1295 treatment helped maintain normal growth in GH-deficient mice. Furthermore, after once-daily injections of this synthetic peptide for 5 weeks, the group administered CJC-1295 exhibited normal total body weight. [R]

Promising results such as the above in preclinical studies led to CJC-1295 being investigated as a potential treatment for GHD in humans. However, a phase-2 trial was abruptly halted upon the death of one trial participant. The occurrence was unrelated to CJC-1295 treatment. [R]


4) CJC-1295 and Infertility

A 1991 study indicates that GRF analogs such as CJC-1295 may induce ovulation in infertile female patients.

The investigation enrolled 10 normally ovulating women with infertility due to a tubal or male factor. After administration of GRF in two cycles, the participants’ ovaries showed increased sensitivity and response to gonadotrophins, hormones that are involved in fertility. [R]


Frequently Asked Questions

What does CJC-1295 do?

Clinical studies have shown that CJC-1295 increases the levels of growth hormone and insulin-like growth factor 1 in a dose-related manner. However, it’s important to note that CJC-1295 is not approved for any use by the FDA.


Does CJC-1295 increase testosterone?

While some studies indicate that growth hormone directly stimulates testosterone secretion, no study has reported that CJC-1295 DAC treatment increases testosterone levels. [R]


How much does CJC-1295 increase growth hormone?

In a double-blind, placebo-controlled trial, a single CJC-1295 injection produced a rise in mean plasma GH concentrations by 2- to 10-fold for 6 days.


Does CJC-1295 increase muscle mass or bone density?

No clinical evidence indicates that CJC-1295 treatment leads to increased muscle mass or bone density.



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CJC-1295 is a synthetic analog of GHRH. It is a modified form of GHRH that increases growth hormone release in animals and humans. This growth hormone secretagogue has also been found to stimulate IGF-1 release from the anterior pituitary gland. sells CJC-1205 for laboratory research use only.


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