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Andarine (S-4)


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Buy Andarine (S-4) for Sale

Andarine S4 is a SARM that was developed in the late 1990s. It was initially designed to treat muscle wasting, osteoporosis, and benign prostatic hypertrophy.

Animal studies have shown that Andarine can increase muscle mass, bone mineral density, and strength. Andarine has also been found to stimulate fat loss in lab rats. However, without clinical studies, whether these effects would occur in humans is yet to be determined.


What is Andarine S4?

Andarine S4 is a selective androgen receptor modulator developed by GTX, Inc. (now called Oncternal Therapeutics) in the late 1990s. It was initially designed to treat muscle wasting, osteoporosis, and other conditions associated with muscle and bone loss.

A preclinical study published in 2005 showed that Andarine treatment enhanced muscle mass and strength in female rats who had their ovaries removed. This SARM was also found to significantly increase bone mineral density (BMD) and bone strength. [R]

Another animal study investigated the anabolic effects of Andarine. It was reported that this SARM prevented bone loss and increased bone strength in the treated rats. Andarine treatment was also found to increase lean muscle mass and decrease body fat. [R]

An earlier study reported that S4’s anabolic activity is similar to or greater than that of testosterone propionate, an anabolic steroid. Even though this SARM hasn’t been found to increase prostate weight, one of the key side effects of traditional anabolic steroids. [R]


How Does Andarine S4 Work?

Andarine works by attaching to androgen receptors in the muscle and bone tissue. Research has shown that S4 targets ARs on a tissue-selective basis. It mainly binds androgen receptors in the skeletal muscle, sparing the ones in the reproductive organs.

An animal study published in 2003 confirmed the above. It showed that while S4 was less potent than testosterone propionate in stimulating androgenic activity, its anabolic activity was similar to or greater than the anabolic steroid, even at similar doses. [R]


Andarine Research

No human studies have been conducted on Andarine to date. However, multiple animal studies have investigated its effects on muscle growth, prostate gland, and bone strength. Here are the key findings extracted from those preclinical studies:


Andarine and Muscle Mass

Multiple animal studies have investigated the effects of S4 on muscle mass.

In a 2003 study involving ovariectomized rats, Andarine treatment for 4 weeks significantly increased the muscle weight of levator ani, a group of muscles located in the pelvis. Equally importantly, S4 didn’t elevate the prostate weight above normal. [R]

Another study reported that S4 treatment improved muscle strength and body composition in male rats with one or both testicles removed. The study further noted that these effects were achieved with minimal pharmacologic effects in the prostate. [R]


Andarine and Bone Density

In the above study, S4 treatment was found to prevent bone loss. This SARM was also reported to increase total bone mineral density. Significantly, the increase in BMD was found to be greater than the one brought about by DHT. [R]

Another study reported similar effects of S4 in ovariectomized rats. It noted that S4 treatment for two months significantly increased the BMD and strength of the femoral cortical bone. Both effects were observed without enlargement of the prostate. [R]


Andarine and Fat Loss

Andarine has been found to cause fat loss in ovariectomized rats.

A 2006 study reported that S4 treatment caused a dose-dependent decrease in body fat. The animals who experienced these effects had their ovaries removed before the study. Also, in addition to decreasing fat mass, S-4 increased lean mass percentage. [R]


Andarine and Muscle Strength

At least two studies have examined the effects of S4 on muscle strength.

The first study reported that S4 restored skeletal muscle strength and body composition in castrated male rats. This investigation was followed up by another preclinical study which showed that ovariectomized female rats also experienced increased muscle strength following S4 treatment. [R][R]



What is the half-life of Andarine?

Andarine reportedly has a relatively short half-life of 4-6 hours.


What does Andarine do to the body?

In the absence of human studies, it cannot be stated what effects, if any, Andarine would exert on the body. However, animal studies have shown that it can increase lean muscle mass, improve muscle strength, and reduce body fat.


Is Andarine good for fat loss?

In animal studies, Andarine has been found to cause significant fat loss. However, no clinical study has investigated its effects on humans to date.


Is Andarine legal?

Andarine is not approved for human consumption by the FDA. However, it’s available for purchase as a research chemical.


Does Andarine suppress testosterone?

In the preclinical studies conducted on Andarine to date, no suppression of testosterone has been observed. However, human studies are needed to validate the effects of this androgen receptor agonist on testosterone.


Where to Buy Andarine for Sale? is the best place to buy S4 for sale.

We have been around since 2023, supplying the highest-quality research compounds money can buy. Our products come with a 100% satisfaction guarantee, fast shipping, and great customer service to turn every customer into a repeat customer.



Andarine S4 is a full androgen receptor agonist that has been reported to have a high oral bioavailability. In animal studies, it has been shown to increase lean muscle mass, decrease body fat, and enhance bone mineral density in animal studies. sells Andarine for laboratory research use only.


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